Misión San Francisco de Asís3321 16th St, San Francisco
Embrace San Francisco history that goes way back—before any tech boom, or even the Gold Rush. Misión San Francisco de Asís is the oldest building in the city, dating to 1776 when Father Junípero Serra established a string of missions to convert indigenous populations and bolster Spain’s presence in the New World. Nearly 250 years later, the church—named for St. Francis of Assisi, but also known as Mission Dolores, after the nearby creek—still hosts an active congregation. Stop by for services or tour the historic cemeteries and gardens. Check out the basilica’s dazzling stained glass windows, which depict all 21 missions.